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| Nomenclature |
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Symbol:
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Pla2g6tm1Turk
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Name:
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phospholipase A2, group VI;
targeted mutation 1, John Turk
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MGI ID: |
MGI:3055154 |
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Synonyms: |
IPLA2beta- |
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Gene:
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Pla2g6
Location:
Chr15:79286228-79328390 bp, - strand
Genetic Position: Chr15,
37.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92835
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exon 9. Northern blot and Western blot demonstrated lack of transcript and protein in mutant tissues. (J:92835)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pla2g6 Mutation:
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22 strains or lines available |
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Notes |
This model of infantile neuroaxonal dystrophy has a later onset in mouse than in human
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| References |
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Original: |
J:92835
Bao S et al.,
"Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility."
J Biol Chem 2004 Sep 10;279(37):38194-200
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All: |
20 reference(s)
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Analysis Tools
