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| Nomenclature |
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Symbol:
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Tg(DM15)26Bew
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Name:
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transgene insertion 26, Be Wieringa
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MGI ID: |
MGI:3054417 |
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Transgene:
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Tg(DM15)26Bew
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains a 14 kb genomic fragment including all of the human DM15 gene and the last exon from the upstream gene DMWD. Two founder lines were generated Tg26 and Tg15 with 25 and 20 copies of the transgene integrated, respectively. Expression is seen in the muscle and smooth muscle containing tissues. Tg26 has a higher level of expression and more severe phenotype compared to Tg15 which has lower expression and a milder version of the same phenotype seen in Tg26. (J:33711)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Younger mice do not exhibit typical symptoms of Dystrophia Myotonica 1 (J:33711), however older mice (11-15 months of age) develop the distinctive traits of Dystrophia Myotonica 1 (J:93614).
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| References |
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Original: |
J:33711
Jansen G et al.,
"Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice [see comments]"
Nat Genet 1996 Jul;13(3):316-24
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All: |
2 reference(s)
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Analysis Tools
