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| Nomenclature |
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Symbol:
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Tg(AQP2-cre)2Dek
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Name:
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transgene insertion 2, Donald E Kohan
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MGI ID: |
MGI:3054057 |
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Transgene:
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Tg(AQP2-cre)2Dek
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of 14 kb from the 5'-flanking region of the human AQP2 driving expression of a modified cre recombinase that includes an SV40 nuclear localization signal and an 11 amino acid herpes simplex virus glycoprotein D epitope tag. Cre expression is seen in the collecting ducts of the kidney, the vas deferens, and the testis including post-meiotic sperm. Paternal inheritance of this transgene results in ubiquitous cre mediated recombination. (J:52357)
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Recombinase activity
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Driver:
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AQP2
Summary of all recombinase alleles
driven by AQP2.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:52357
Nelson RD et al.,
"Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice."
Am J Physiol 1998 Jul;275(1 Pt 1):C216-26
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All: |
8 reference(s)
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Analysis Tools
