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| Nomenclature |
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Symbol:
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Tg(Vil-cre/ERT2)23Syr
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Name:
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transgene insertion 23, Sylvie Robine
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MGI ID: |
MGI:3053826 |
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Synonyms: |
TgvCreERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, villin::CreERT2, Villin-Cre(ER-T2), Villin-CreERT2 |
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Transgene:
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Tg(Vil-cre/ERT2)23Syr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: A 9 kb segment of the regulatory region of the mouse Vil gene drives expression of cre recombinase fused to a mutated ligand binding domain of the human estrogen receptor. Cre recombination is inducible with tamoxifen treatment in epithelial cells all along the crypt-villus axis and in undifferentiated progenitor cells in the crypt region. This is a representative record for the two lines generated (Fo23 and Fo24) that have the same inducible expression pattern. Only 1 copy of the transgene integrated in these lines. (J:92295)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:92295
el Marjou F et al.,
"Tissue-specific and inducible Cre-mediated recombination in the gut epithelium."
Genesis 2004 Jul;39(3):186-93
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All: |
56 reference(s)
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Analysis Tools
