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| Nomenclature |
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Symbol:
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Plscr3tm1Sims
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Name:
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phospholipid scramblase 3;
targeted mutation 1, Peter J Sims
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MGI ID: |
MGI:3053448 |
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Synonyms: |
PLSCR3-, Plscr3Gt(Betageo)1Sims |
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Gene:
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Plscr3
Location:
Chr11:69846376-69851043 bp, + strand
Genetic Position: Chr11,
42.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92404
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A gene trap vector containing pKOS-lacZ/MC1neo (Lexicon Genetics, Woodlands, TX) was inserted to replace the first four exons of the gene. Western blot analysis on platelets, lung, muscle and adipocytes did not detect protein. (J:92404)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Plscr3 Mutation:
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3 strains or lines available |
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Notes |
ES cell line derived from 129S/SvEvBrd.
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| References |
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Original: |
J:92404
Wiedmer T et al.,
"Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)."
Proc Natl Acad Sci U S A 2004 Sep 7;101(36):13296-301
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All: |
2 reference(s)
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Analysis Tools
