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| Nomenclature |
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Symbol:
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Tnfrsf1atm1Gkl
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Name:
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tumor necrosis factor receptor superfamily, member 1a;
targeted mutation 1, George Kollias
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MGI ID: |
MGI:3053140 |
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Synonyms: |
P55deltaNS |
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Gene:
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Tnfrsf1a
Location:
Chr6:125349362-125362484 bp, + strand
Genetic Position: Chr6,
59.32 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92470
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A targeting vector was designed to delete 15 nucleotides in exon 6 encoding amino acids 202-206. Southern blot and PCR confirmed recombination. Flow cytometry of peritoneal cells indicated that the mutation abolished receptor shedding. (J:92470)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:92470
Xanthoulea S et al.,
"Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases."
J Exp Med 2004 Aug 2;200(3):367-76
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All: |
1 reference(s)
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Analysis Tools
