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| Nomenclature |
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Symbol:
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Fgfr2tm4Lni
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 4, Peter Lonai
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MGI ID: |
MGI:3053095 |
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Synonyms: |
Fgfr2cC342Y |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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+/+ wildtype and Fgfr2tm4Lni/+ skull phenotypes and histological sections.
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92433
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A C342Y replacement was inserted into exon 9 (the IIIc exon) and a floxed neo into intron 9. Mating with mice expressing cre in the germ line excised the floxed neo. (J:92433)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:92433
Eswarakumar VP et al.,
"A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis."
Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12555-60
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All: |
2 reference(s)
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Analysis Tools
