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| Nomenclature |
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Symbol:
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Tg(BCL2)22Wehi
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Name:
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transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
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MGI ID: |
MGI:3052827 |
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Synonyms: |
22Wehi, C-Emu-bcl-2-22, Emu2-22, Emu-bcl-2, Emu-bcl-2-22, EmuBcl-2.22, SV40-E-hbcl-2-22 |
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Transgene:
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Tg(BCL2)22Wehi
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6JWehi x SJL/JWehi)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct consists of the human BCL2 cDNA in association with the Emu immunoglobulin heavy chain enhancer and SV40 promoter. (J:93111)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
In transgenic mice on a C57BL/6 background, expression of the transgene is restricted to the B cell lineage (no T-cell expression).
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| References |
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Original: |
J:93111
Strasser A et al.,
"Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice."
Curr Top Microbiol Immunol 1990;166():175-81
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All: |
68 reference(s)
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Analysis Tools
