|
|
| Nomenclature |
|
Symbol:
|
Prnptm1Tuzi
|
|
Name:
|
prion protein;
targeted mutation 1, Nadia L Tuzi
|
|
MGI ID: |
MGI:3052798 |
|
Synonyms: |
Prpstop |
|
Gene:
|
Prnp
Location:
Chr2:131909928-131938429 bp, + strand
Genetic Position: Chr2,
64.07 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:92302
|
|
Parent Cell Line:
| HM-1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd-Hprtb-m3
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A floxed Betageo cassette was inserted into intron 2. PCR confirmed recombination in mice. Northern blot demonstrated that transcription was abolished and Western blot indicated a complete absence of protein in mutant brains. (J:92302)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Prnp Mutation:
|
71 strains or lines available |
|
| References |
|
Original: |
J:92302
Tuzi NL et al.,
"Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases."
Genesis 2004 Sep;40(1):1-6
|
|
All: |
2 reference(s)
|
|
Analysis Tools
