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| Nomenclature |
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Symbol:
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Trex1tm1Tld
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Name:
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three prime repair exonuclease 1;
targeted mutation 1, Tomas Lindahl
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MGI ID: |
MGI:3052754 |
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Synonyms: |
Trex1- |
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Gene:
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Trex1
Location:
Chr9:109057933-109060338 bp, - strand
Genetic Position: Chr9,
59.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92264
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Parent Cell Line:
| GK129 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neo replaced sequence encoding amino acids 103-207 of the ORF product, including conserved exonuclease magnesium binding motifs II and III. RT-PCR showed no transcript present in mutant spleens. Mutant livers did not demonstrate protein in Western blot analysis. (J:92264)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Trex1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:92264
Morita M et al.,
"Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis."
Mol Cell Biol 2004 Aug;24(15):6719-27
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All: |
6 reference(s)
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Analysis Tools
