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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(Luc)Kael
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, William G Kaelin
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MGI ID: |
MGI:3052356 |
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Synonyms: |
ROSA26 L-S-L-Luc |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92043
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: The endogenous locus is interrupted by a construct comprising a loxP site, a neomycin resistance cassette with a strong, triple SV40 polyadenylation signal, and a second loxP site in the same orientation as the first followed by the cDNA sequence encoding firefly luciferase and the bovine growth hormone polyadenylation signal. In cells in which Cre recombinase is expressed, the DNA between the loxP sites is excised, along with one loxP site, permitting expression of the luciferase gene under control of the ubiquitous ROSA26 promoter. (J:92043)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:92043
Safran M et al.,
"Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination."
Mol Imaging 2003 Oct;2(4):297-302
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All: |
8 reference(s)
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Analysis Tools
