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| Nomenclature |
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Symbol:
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Ciitatm2Wrth
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Name:
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class II transactivator;
targeted mutation 2, Walter Reith
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MGI ID: |
MGI:3052223 |
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Synonyms: |
C2ta p(III+IV)-, CiitaIII-IV-, CIITA p(III+IV)-, PIII+IV- |
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Gene:
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Ciita
Location:
Chr16:10488178-10527564 bp, + strand
Genetic Position: Chr16,
5.65 cM, cytoband B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92170
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A loxP site was inserted 560 bp upstream of the ATG for the pIII transcript and another loxP site was inserted 90 bp downstream of the first exon encoding the pIV transcript, followed by an FRT-flanked neo. Transient FLP recombinase expression excised the neo and mice generated were crossed with CMV-Cre mice to excise the floxed pIII and pIV sequence. RT-PCR indicated transcripts of both were undetectable in mutant tissues. Gene expression from pI was unaffected. (J:92170)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ciita Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:92170
LeibundGut-Landmann S et al.,
"MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells."
Nat Immunol 2004 Sep;5(9):899-908
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All: |
6 reference(s)
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Analysis Tools
