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| Nomenclature |
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Symbol:
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Hrtm1Cct
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Name:
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hairless;
targeted mutation 1, Catherine C Thompson
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MGI ID: |
MGI:3052135 |
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Synonyms: |
Hr- |
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Gene:
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Hr
Location:
Chr14:70552212-70573548 bp, + strand
Genetic Position: Chr14,
36.32 cM
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Characterization of the Hrtm1Cct/Hrtm1Cct mouse
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92053
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 8-10 were replaced with a floxed PGK-neo cassette. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. (J:92053)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:92053
Zarach JM et al.,
"The co-repressor hairless has a role in epithelial cell differentiation in the skin."
Development 2004 Sep;131(17):4189-200
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All: |
2 reference(s)
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Analysis Tools
