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| Nomenclature |
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Symbol:
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Disp1tm1Amc
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Name:
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dispatched homolog 1 (Drosophila);
targeted mutation 1, Andrew P McMahon
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MGI ID: |
MGI:3052133 |
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Synonyms: |
Disp1delta2 |
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Gene:
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Disp1
Location:
Chr1:183086264-183221529 bp, - strand
Genetic Position: Chr1,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92058
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Parent Cell Line:
| AV3 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A targeting vector was designed to flank exon 2, containing an initiation site and N-terminal 168 amino acids, with loxP sites. Cre expression in the germ line excised exon 2, leaving a single loxP site. Analysis of transcripts suggests that, in the absence of exon 2, exon 1B was replaced by exon 1A, which was spliced to exon 3, thereby allowing translation from an initiation codon in exon 4. The result was a N-terminal truncated transcript. Southern blot confirmed absence of exon 2 in mutant mice with this putatively hypomorphic allele. (J:92058)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Disp1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:92058
Tian H et al.,
"Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse."
Development 2004 Aug;131(16):4021-33
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All: |
2 reference(s)
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Analysis Tools
