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| Nomenclature |
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Symbol:
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Crb1tm1Wij
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Name:
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crumbs homolog 1 (Drosophila);
targeted mutation, Jan Wijnholds
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MGI ID: |
MGI:3052072 |
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Synonyms: |
Crb1- |
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Gene:
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Crb1
Location:
Chr1:139197056-139377100 bp, - strand
Genetic Position: Chr1,
60.87 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92068
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A hygromycin resistance cassette replaced 2.9 kb of the upstream promoter region, exon 1 and part of intron 1. Southern blot confirmed a smaller product size and immunoprecipitation indicated no detectable protein. (J:92068)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Crb1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:92068
Van De Pavert SA et al.,
"Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
J Cell Sci 2004 Aug 15;117(Pt 18):4169-77
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All: |
7 reference(s)
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Analysis Tools
