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| Nomenclature |
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Symbol:
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Slc29a1tm1Msg
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Name:
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solute carrier family 29 (nucleoside transporters), member 1;
targeted mutation 1, Robert O Messing
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MGI ID: |
MGI:3052066 |
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Synonyms: |
ENT1- |
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Gene:
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Slc29a1
Location:
Chr17:45585200-45599606 bp, - strand
Genetic Position: Chr17,
22.59 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:92100
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The targeting construct included exons 2-4 of the gene and a neomycin cassette flanked by loxP sequences. Clones were transfected with a Cre plasmid. ES cell lines showing a deletion of exons 2-4 and the neomycin cassette were selected for microinjection. The mutation was confirmed by PCR, Southern blot and in situ hybridization. (J:92100)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line derived from 129X1/SvJ
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| References |
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Original: |
J:92100
Choi DS et al.,
"The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference."
Nat Neurosci 2004 Aug;7(8):855-61
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All: |
9 reference(s)
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Analysis Tools
