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| Nomenclature |
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Symbol:
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Ptprn2tm1Aln
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Name:
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protein tyrosine phosphatase, receptor type, N polypeptide 2;
targeted mutation 1, Abner Louis Notkins
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MGI ID: |
MGI:3051779 |
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Synonyms: |
IA-2Beta- |
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Gene:
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Ptprn2
Location:
Chr12:116485720-117278167 bp, + strand
Genetic Position: Chr12,
62.65 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:91889
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced part of the 5' upstream promoter, exon 1 and part of intron 1, including the AUG start codon, 106 additional codons and a 5' UTR of at least 145 nucleotides. Northern blot indicated absence of transcript in brains of mutant mice. Further confirmation was provided by Western blot analysis showing lack of wild-type protein in brains of mutant mice. (J:91889)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptprn2 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:91889
Kubosaki A et al.,
"Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice."
Diabetes 2004 Jul;53(7):1684-91
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All: |
6 reference(s)
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Analysis Tools
