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| Nomenclature |
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Symbol:
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Cyb5r4tm1Hfb
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Name:
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cytochrome b5 reductase 4;
targeted mutation 1, H Franklin Bunn
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MGI ID: |
MGI:3050973 |
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Synonyms: |
Ncb5or- |
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Gene:
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Cyb5r4
Location:
Chr9:87022014-87077774 bp, + strand
Genetic Position: Chr9,
46.69 cM
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Immunohistochemical and ultrastructural assessment of insulin- and glucagon-producing cells in Cyb5r4tm1Hfb/Cyb5r4tm1Hfb mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:91486
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 4, which contains sequence encoding the heme-binding domain, was replaced with a PGK-hygromycin gene. Mutant mice did not express full length mRNA or protein, as shown by Northern blot and Western blot, respectively. (J:91486)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:91486
Xie J et al.,
"Absence of a reductase, NCB5OR, causes insulin-deficient diabetes."
Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10750-5
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All: |
5 reference(s)
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Analysis Tools
