Tg(MMTV-Erbb2)NK1Mul
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(MMTV-Erbb2)NK1Mul
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Name:
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transgene insertion NK1, William Muller
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MGI ID: |
MGI:3050871 |
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Synonyms: |
HER-2/neu, MMTV c-neu, MMTV-erbB2, MMTV-neu, MMTV-Tg.NK, Tg(MMTV-Erbb2)1Led, TG.NK |
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Transgene:
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Tg(MMTV-Erbb2)NK1Mul
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains the MMTV (mouse mammary tumor virus) LTR promoter, a 4.6 kb cDNA from the rat Erbb2 (avian erythroblastosis B2) oncogene, and an SV40 polyadenylation site sequence. The activated form of the rat gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. Non-uniform and random transgene expression is detected by RNase protection assay in mammary gland epithelium from hemizygous transgenic mice. Six transgenic lines were produced (NA, NB, NF, NK, NL and NM). (J:48632)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Tumor formation in transgenic mice is multifocal, stochastic, and matches the expression pattern of the transgene. While no transgene expression is detected at 5 and 8 weeks of age in normal mammary gland tissue, expression is detected in adenocarcinomas from older (23 week old) mice. 50% of transgenic mice derived from this founder line develop tumors within 6-12 months of age.
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| References |
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Original: |
J:48632
Muller WJ et al.,
"Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene."
Cell 1988 Jul 1;54(1):105-15
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All: |
53 reference(s)
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Analysis Tools
