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| Nomenclature |
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Symbol:
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Fzd6tm1Nat
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Name:
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frizzled homolog 6 (Drosophila);
targeted mutation 1, Jeremy Nathans
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MGI ID: |
MGI:3050103 |
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Synonyms: |
Fz6- |
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Gene:
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Fzd6
Location:
Chr15:39006280-39038186 bp, + strand
Genetic Position: Chr15,
15.22 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:91412
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: nLacZ and a floxed neo was inserted in place of codons 1-125, which encode the signal sequence and most of the cystein-rich ligand-binding domain. PCR confirmed integration of neo and the absence of endogenous sequence and X-gal staining of mutant skin showed that the gene was expressed. Western blot against the C-terminal 17 amino acids of the endogenous gene demonstrated its absence in mutant skin. The floxed neo was later removed through crossing with germ-line cre mice. (J:91412)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:91412
Guo N et al.,
"Frizzled6 controls hair patterning in mice."
Proc Natl Acad Sci U S A 2004 Jun 22;101(25):9277-81
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All: |
10 reference(s)
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Analysis Tools
