|
|
| Nomenclature |
|
Symbol:
|
Tg(TTR-V30M)15Imeg
|
|
Name:
|
transgene insertion 15, Institute of Molecular Embryology and Genetics
|
|
MGI ID: |
MGI:3047080 |
|
Synonyms: |
6.0-hMet30, 6.0-Met30, Tg(6.0-hV30M)14Imeg, Tg(TTR)15Imeg, Tg(TTR-V30M)15Imeg, Tg(TTR-Val30Met)15Imeg |
|
Transgene:
|
Tg(TTR-V30M)15Imeg
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The targeting construct contained 6.0 kb of the upstream region and the entire coding region of the human transthyretin gene. The coding sequence contained a methionine to valine substitution mutation at position 30. Transgenic transthyretin transcript was detected in liver, brain, kidney, and yolk sac. In some cases aberrant transcript that was larger than normal transcript was detected. (J:91391)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
|
Notes |
Of the eight transgenic lines produced in J:91391, 5 produced serum levels of transthyretin that were higher than those found in patients with familial amyloidotic polyneuropathy (FAP), these were lines: 15, 21, 24, 37 and 40.
|
| References |
|
Original: |
J:91391
Nagata Y et al.,
"A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse."
J Biochem 1995 Jan;117(1):169-75
|
|
All: |
9 reference(s)
|
|
Analysis Tools
