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| Nomenclature |
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Symbol:
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Tg(Igk-V21-Bax)1967Bvn
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Name:
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transgene insertion 1967, Brian Van Ness
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MGI ID: |
MGI:3046400 |
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Synonyms: |
KE/Bcl-XL |
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Transgene:
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Tg(Igk-V21-Bax)1967Bvn
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of 3' enhancer and promoter sequence from the mouse Igk-V21, a flag epitope fused to mouse Bax cDNA, and the 3'UTR from the human growth hormone gene. The highest levels of expression of this transgene are found in the marrow, spleen and lymph nodes. Expression is also restricted to immature/transitional B cells. Three founder lines were generated 1962, 1967 and 2021. (J:89049)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:89049
Linden M et al.,
"Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies."
Blood 2004 Apr 1;103(7):2779-86
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All: |
5 reference(s)
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Analysis Tools
