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| Nomenclature |
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Symbol:
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Rhotm2Jhw
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Name:
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rhodopsin;
targeted mutation 2, John H Wilson
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MGI ID: |
MGI:3046186 |
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Synonyms: |
hrhoG, RGFP, Rho-eGFP |
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Gene:
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Rho
Location:
Chr6:115931927-115938829 bp, + strand
Genetic Position: Chr6,
53.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:91038
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The endogenous gene was first replaced with an HPRT minigene and then the HPRT minigene was replaced with the human RHO gene fused to GFP via homologous recombination. Western blot analysis indicated that expression of the human gene was about 80% that of the endogenous gene. GFP expression is seen in the eyes. (J:91038)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rho Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:91038
Chan F et al.,
"Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy."
Proc Natl Acad Sci U S A 2004 Jun 15;101(24):9109-14
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All: |
8 reference(s)
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Analysis Tools
