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| Nomenclature |
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Symbol:
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Tlr7tm1Aki
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Name:
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toll-like receptor 7;
targeted mutation 1, Shizuo Akira
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MGI ID: |
MGI:3045662 |
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Synonyms: |
Tlr7- |
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Gene:
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Tlr7
Location:
ChrX:167304929-167330558 bp, - strand
Genetic Position: ChrX,
78.31 cM, cytoband F5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90979
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neo replaced 1.8 kb of sequence that encodes a part of a leucine-rich repeat by homologous recombination. Recombination was confirmed by Southern analysis of tails from mutant males. (J:90979)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:90979
Hemmi H et al.,
"Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway."
Nat Immunol 2002 Feb;3(2):196-200
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All: |
86 reference(s)
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Analysis Tools
