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| Nomenclature |
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Symbol:
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Terttm1Leah
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Name:
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telomerase reverse transcriptase;
targeted mutation 1, Lea Harrington
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MGI ID: |
MGI:3044918 |
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Synonyms: |
mTert-, Tertdelta |
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Gene:
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Tert
Location:
Chr13:73627001-73649041 bp, + strand
Genetic Position: Chr13,
40.12 cM
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Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90866
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Five exons were replaced with a neomycin selection cassette inserted by homologous recombination. The deletion was reported to disrupt the telomerase-specific motif as well as the first three of the seven reverse transcriptase motifs. Transcript was undetected in homozygous mutant ES cells and in testicular tissue from first generation homozygous mutant mice, as shown by RT-PCR analysis. No telomerase activity was detected in homozygous mutant ES cell clones and in tissue extracts from homozygous mutant testes, liver, thymus, lung and kidney, as determined by TRAP analysis. (J:90866)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:90866
Liu Y et al.,
"The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo."
Curr Biol 2000 Nov 16;10(22):1459-62
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All: |
11 reference(s)
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Analysis Tools
