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| Nomenclature |
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Symbol:
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Tg(ACTB-NOTCH1)1Shn
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Name:
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transgene insertion 1, Jie Shen
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MGI ID: |
MGI:3044583 |
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Synonyms: |
CALSL-NICD |
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Transgene:
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Tg(ACTB-NOTCH1)1Shn
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304), and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 10 - 20 copies of the transgene and protein is detectable by western blot analysis after cre mediated recombination. (J:90392)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:90392
Yang X et al.,
"Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway."
Dev Biol 2004 May 1;269(1):81-94
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All: |
5 reference(s)
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Analysis Tools
