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| Nomenclature |
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Symbol:
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Edn1tm1Ywa
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Name:
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endothelin 1;
targeted mutation 1, Masashi Yanagisawa
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MGI ID: |
MGI:3044563 |
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Synonyms: |
ET-1flox |
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Gene:
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Edn1
Location:
Chr13:42301270-42307989 bp, + strand
Genetic Position: Chr13,
20.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90390
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Southern blot and RT-PCR indicate presence of recombinant transcript. (J:90390)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Edn1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:90390
Shohet RV et al.,
"Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy."
Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2088-93
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All: |
14 reference(s)
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Analysis Tools
