Tg(TcraH-Y,TcrbH-Y)71Vbo
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(TcraH-Y,TcrbH-Y)71Vbo
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Name:
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transgene insertion 71, Harald von Boehmer
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MGI ID: |
MGI:3044562 |
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Synonyms: |
B6.2.16, HY, H-Y, HY1.1, HY1.1 (Tcr-ab), H-Y TCR, HY TCR, HY-TCR, HY_TCRtg, H-Y Tg, T-cell receptor (alpha/beta) anti-Hy, TCR HY, Tg71 |
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Transgene:
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Tg(TcraH-Y,TcrbH-Y)71Vbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x DBA/2J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The two transgenes comprise functionally rearranged T-cell receptor alpha and T-cell receptor beta genes, isolated from the cytotoxic T cell clone B6.2.16, that recognize the male-specific H-Y antigen in the context of the H2-Db major histocompatibilty protein. The alpha chain transgene has the V-alpha3 gene segment joined to the J-alpha27 segment; the beta chain transgene joins V-beta8.2, D-beta1, J-beta2.3 and C-beta2. The two transgenes were coinjected into fertilized oocytes. The founder of line 71 carried four copies of the rearranged T-cell receptor alpha and two copies of the T-cell receptor beta transgenes. (J:51117, J:79738, J:90776)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79738
Kisielow P et al.,
"Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes."
Nature 1988 Jun 23;333(6175):742-6
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All: |
186 reference(s)
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Analysis Tools
