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| Nomenclature |
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Symbol:
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Twist2tm1(cre)Dor
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Name:
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twist basic helix-loop-helix transcription factor 2;
targeted mutation 1, David M Ornitz
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MGI ID: |
MGI:3044412 |
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Synonyms: |
Dermo1cre, Dermo-1Cre, Dermo1-Cre, Dermocre, DM1-Cre, twist-2-, Twist2tm1(cre)Eno |
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Gene:
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Twist2
Location:
Chr1:91801461-91848028 bp, + strand
Genetic Position: Chr1,
46.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:81485
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a cre recombinase gene and an FRT-flanked neo cassette. Southern blot analysis confirmed recombination. Cre was expressed in the developing skeleton, specifically in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages. (J:90391)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Twist2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:81485
Sosic D et al.,
"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."
Cell 2003 Jan 24;112(2):169-80
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All: |
40 reference(s)
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Analysis Tools
