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| Nomenclature |
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Symbol:
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Twsg1tm1Emdr
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Name:
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twisted gastrulation homolog 1 (Drosophila);
targeted mutation 1, E M De Robertis
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MGI ID: |
MGI:3044357 |
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Synonyms: |
Tsg-, Twsg1lacZ |
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Gene:
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Twsg1
Location:
Chr17:65923066-65951187 bp, - strand
Genetic Position: Chr17,
35.26 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90398
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: In-frame insertion of a lacZ reporter into exon 1 at the start codon resulted in the deletion of exon 1, which encodes the first 40 amino acids of the protein, including the entire signal peptide. RT-PCR indicated no transcript present in mutant embryonic cells. (J:90398)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:90398
Zakin L et al.,
"Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development."
Development 2004 Jan;131(2):413-24
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All: |
4 reference(s)
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Analysis Tools
