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| Nomenclature |
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Symbol:
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Apptm1Ini
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Name:
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amyloid beta (A4) precursor protein;
targeted mutation 1, Ikuo Nishimoto
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MGI ID: |
MGI:3044176 |
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Synonyms: |
V642I-APP-KI |
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Gene:
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App
Location:
Chr16:84954440-85173707 bp, - strand
Genetic Position: Chr16,
46.92 cM, cytoband C3-qter
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90296
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A point mutation was introduced into exon 17 causing a valine to isoleucine change at amino acid residue 642 together with a floxed neomycin resistance gene in intron 17. The neomycin gene was subsequently excised from correctly targeted clones by transient cre expression. The mutation was confirmed in mice by genomic DNA sequencing. (J:90296, J:90561)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any App Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:90296
Kawasumi M et al.,
"Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice."
Eur J Neurosci 2004 May;19(10):2826-38
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All: |
2 reference(s)
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Analysis Tools
