|
|
| Nomenclature |
|
Symbol:
|
Wfs1tm1Yoka
|
|
Name:
|
Wolfram syndrome 1 homolog (human);
targeted mutation 1, Yoshitomo Oka
|
|
MGI ID: |
MGI:3044175 |
|
Synonyms: |
wfs1- |
|
Gene:
|
Wfs1
Location:
Chr5:36966104-36988982 bp, - strand
Genetic Position: Chr5,
19.46 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:90420
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A neomycin-resistance gene was inserted into the second exon, which contains the initial ATG codon. Western blot indicated absence of protein in mutant brains. (J:90420)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Wfs1 Mutation:
|
6 strains or lines available |
|
| References |
|
Original: |
J:90420
Ishihara H et al.,
"Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion."
Hum Mol Genet 2004 Jun 1;13(11):1159-70
|
|
All: |
6 reference(s)
|
|
Analysis Tools
