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| Nomenclature |
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Symbol:
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Trhrtm1Bau
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Name:
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thyrotropin releasing hormone receptor;
targeted mutation 1, Karl Bauer
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MGI ID: |
MGI:3044170 |
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Synonyms: |
THR-R1-, trhr1ko |
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Gene:
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Trhr
Location:
Chr15:44196135-44235912 bp, + strand
Genetic Position: Chr15,
16.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90365
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The complete coding region encompassing the transcriptional start site in exon 2 and spanning part of exon 5 was replaced with LacZ and neo cassettes. Northern blot confirmed absence of transcript in pituitary glands of mutants. (J:90365)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Trhr Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:90365
Rabeler R et al.,
"Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism."
Mol Endocrinol 2004 Jun;18(6):1450-60
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All: |
2 reference(s)
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Analysis Tools
