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| Nomenclature |
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Symbol:
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Tfe3tm1Est
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Name:
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transcription factor E3;
targeted mutation 1, Eirikur Steingrimsson
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MGI ID: |
MGI:3044119 |
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Synonyms: |
Tcfe3-, Tfe3Fcr |
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Gene:
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Tfe3
Location:
ChrX:7762560-7775202 bp, + strand
Genetic Position: ChrX,
3.5 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89821
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 5.5 kb genomic fragment encompassing 7 exons and encoding the bHLH-Zip domains was replaced with a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of renal RNA obtained from hemizygous mutant mice. (J:89821)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tfe3 Mutation:
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19 strains or lines available |
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| References |
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Original: |
J:89821
Steingrimsson E et al.,
"Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development."
Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4477-82
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All: |
2 reference(s)
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Analysis Tools
