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| Nomenclature |
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Symbol:
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Ptpn22tm2Achn
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Name:
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protein tyrosine phosphatase, non-receptor type 22 (lymphoid);
targeted mutation 2, Andrew C Chan
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MGI ID: |
MGI:3043477 |
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Synonyms: |
pep-, pep(E1)- |
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Gene:
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Ptpn22
Location:
Chr3:103859795-103912247 bp, + strand
Genetic Position: Chr3,
45.52 cM, cytoband F3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90029
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: The translation initiation methionine in exon 1 was mutated from ATGG to CTGC and a puromycin resistance cassette added via homologous recombination. Immunoblot analysis confirmed the absence of wild type or truncated protein in thymocytes and splenocytes from homozygotes. (J:90029)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptpn22 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:90029
Hasegawa K et al.,
"PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells."
Science 2004 Jan 30;303(5658):685-9
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All: |
4 reference(s)
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Analysis Tools
