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| Nomenclature |
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Symbol:
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Uacatm1Kiy
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Name:
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uveal autoantigen with coiled-coil domains and ankyrin repeats;
targeted mutation 1, Kiyoshi Fukui
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MGI ID: |
MGI:3043446 |
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Synonyms: |
Nucling- |
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Gene:
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Uaca
Location:
Chr9:60794548-60880370 bp, + strand
Genetic Position: Chr9,
32.93 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89918
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Parent Cell Line:
| E14K (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A PGK-neo was inserted into the exon encoding the LZ motif. Northern blot and Western blot confirmed gene disruption by lack of transcript in heart and skeletal muscle and protein in MEFs, respectively. (J:93333)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Uaca Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:89918
Liu L et al.,
"Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling."
Biochem J 2004 May 15;380(Pt 1):31-41
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All: |
4 reference(s)
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Analysis Tools
