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| Nomenclature |
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Symbol:
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Trp53tm1Elee
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Name:
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transformation related protein 53;
targeted mutation 1, Eva YHP Lee
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MGI ID: |
MGI:3043426 |
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Synonyms: |
p53f5&6, p53flox, p53fp, p53koflox |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:90247
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exons 5 and 6 were flanked by single loxP sites in introns 4 and 6. Recombination of these loxP sites will result in the deletion of codons 123 through 221, which encode part of the DNA-binding domain. (J:90247)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Glioblastoma Multiforme (J:149662)
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| References |
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Original: |
J:90247
Lin SC et al.,
"Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis."
Cancer Res 2004 May 15;64(10):3525-32
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All: |
13 reference(s)
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Analysis Tools
