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| Nomenclature |
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Symbol:
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Ndrg1tm1Myta
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Name:
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N-myc downstream regulated gene 1;
targeted mutation 1, Toshiyuki Miyata
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MGI ID: |
MGI:3043362 |
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Synonyms: |
Ndrg1- |
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Gene:
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Ndrg1
Location:
Chr15:66929321-66969640 bp, - strand
Genetic Position: Chr15,
29.3 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89888
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A single loxP site remained in place of a genomic fragment encompassing the promoter and exon 1 after cre-mediated excision of loxP sites inserted by homologus recombination. The start codon is contained within exon 2 and though neither transcript nor protein was detected in renal tissue via Northern or Western blot analysis, low levels of normal sized transcript and protein were detected in sciatic nerve. (J:89888)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ndrg1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:89888
Okuda T et al.,
"Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves."
Mol Cell Biol 2004 May;24(9):3949-56
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All: |
4 reference(s)
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Analysis Tools
