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| Nomenclature |
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Symbol:
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Mapttm1(Mecp2)Jae
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Name:
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microtubule-associated protein tau;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:3043293 |
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Synonyms: |
Tau-Mecp2 ki |
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Gene:
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Mapt
Location:
Chr11:104231390-104332090 bp, + strand
Genetic Position: Chr11,
67.79 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89593
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The mouse Mecp2 coding sequence, a modified Kozak sequence and a neo-cassette were placed in-frame into exon 1 of Mapt via homologous combination. The resulting fusion protein contained the first 31 amino acids of Mapt fused to Mecp2 and was highly expressed in the brain (in post-mitotic neurons), lung, and kidney. (J:89593)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:89593
Luikenhuis S et al.,
"Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice."
Proc Natl Acad Sci U S A 2004 Apr 20;101(16):6033-8
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All: |
2 reference(s)
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Analysis Tools
