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| Nomenclature |
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Symbol:
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Nrxn1tm1Sud
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Name:
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neurexin I;
targeted mutation 1, Thomas C Sudhof
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MGI ID: |
MGI:3042794 |
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Synonyms: |
Nrxn1alphaKO, SKO2 |
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Gene:
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Nrxn1
Location:
Chr17:90033644-91092805 bp, - strand
Genetic Position: Chr17,
59.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45298
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Protein was undetected by Western blot analysis of mutant mice. (J:45298)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:45298
Geppert M et al.,
"Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action."
J Biol Chem 1998 Jan 16;273(3):1705-10
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All: |
12 reference(s)
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Analysis Tools
