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| Nomenclature |
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Symbol:
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Rps6ka3tm1.1Kry
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Name:
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ribosomal protein S6 kinase polypeptide 3;
targeted mutation 1.1, Gerard Karsenty
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MGI ID: |
MGI:3042586 |
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Synonyms: |
mrsk2-KO, Rsk2- |
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Gene:
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Rps6ka3
Location:
ChrX:159210307-159368244 bp, + strand
Genetic Position: ChrX,
73.27 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89403
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2 was disrupted by the insertion of a floxed neo cassette followed by 3 stop codons. The floxed cassette was removed via Cre-mediated excision, leaving a single loxP site followed by the stop codons. Western blot confirmed absence of protein in mutant cells. (J:89403)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rps6ka3 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:89403
Yang X et al.,
"ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome."
Cell 2004 Apr 30;117(3):387-98
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All: |
9 reference(s)
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Analysis Tools
