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| Nomenclature |
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Symbol:
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Nr1h2tm1Djm
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Name:
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nuclear receptor subfamily 1, group H, member 2;
targeted mutation 1, David J Mangelsdorf
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MGI ID: |
MGI:3041856 |
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Synonyms: |
LXRbeta- |
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Gene:
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Nr1h2
Location:
Chr7:44549616-44553951 bp, - strand
Genetic Position: Chr7,
28.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64343
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a targeting vector replaced exons 5 and 6 with a neomycin resistance cassette creating a null allele. Exons 5 and 6 encode the DNA-binding and ligand-binding domains.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64343
Repa JJ et al.,
"Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments]"
Science 2000 Sep 1;289(5484):1524-9
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All: |
42 reference(s)
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Analysis Tools
