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| Nomenclature |
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Symbol:
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Bmp4tm1Jfm
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Name:
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bone morphogenetic protein 4;
targeted mutation 1, James F Martin
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MGI ID: |
MGI:3041440 |
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Synonyms: |
Bmp4clc, Bmp4floxneo |
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Gene:
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Bmp4
Location:
Chr14:46383520-46390669 bp, - strand
Genetic Position: Chr14,
23.95 cM
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89237
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was introduced upstream of exon 4 and another loxP site followed by a FRT-flanked neo was inserted downstream of exon 4. PCR was used to confirm recombination. (J:89237)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:89237
Liu W et al.,
"Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling."
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4489-94
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All: |
16 reference(s)
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Analysis Tools
