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| Nomenclature |
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Symbol:
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Pomctm1Sora
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Name:
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pro-opiomelanocortin-alpha;
targeted mutation 1, S O'Rahilly
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MGI ID: |
MGI:3040514 |
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Synonyms: |
Pomc- |
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Gene:
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Pomc
Location:
Chr12:3954951-3960618 bp, + strand
Genetic Position: Chr12,
1.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89244
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The majority of exon 3 was replaced with a tau-lacZ reporter and a floxed PGK-neo cassette. A point mutation was introduced into the initiator ATG to create a stop codon. X-gal staining showed beta-galactosidase activity was present in mutant brains. Endogenous mRNA was absent as shown by Northern blot, and a two-site immunoassay confirmed that no peptides were detected in mutant plasma. (J:89244)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pomc Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:89244
Challis BG et al.,
"Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)."
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4695-700
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All: |
10 reference(s)
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Analysis Tools
