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| Nomenclature |
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Symbol:
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Tg(TagRb)1Plm
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Name:
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transgene insertion 1, Pamela L Mellon
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MGI ID: |
MGI:3040285 |
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Synonyms: |
hLHBeta-Tag, hLHB-Tag, LHbeta-Tag, LHBETATAG, LHB-Tag, TAg-RB |
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Transgene:
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Tg(TagRb)1Plm
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x BALB/cJ)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the human luteinizing hormone beta promoter and the wild-type alleles of the SV40 Tag and tag (large and small T antigen) genes. (J:10320)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Fifteen lines were produced. In this line mice developed bilateral ocular neoplasms at about five months of age. Retinal tumors were first observed at about 2 months, and filled the vitreous cavity by 5-6 months of age.
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| References |
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Original: |
J:10320
Windle JJ et al.,
"Retinoblastoma in transgenic mice."
Nature 1990 Feb 15;343(6259):665-9
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All: |
21 reference(s)
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Analysis Tools
