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| Nomenclature |
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Symbol:
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Ctnnb1tm2(Nfkbia)Rsu
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Name:
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catenin (cadherin associated protein), beta 1;
targeted mutation 2, Ruth Schmidt-Ullrich
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MGI ID: |
MGI:3039784 |
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Synonyms: |
cloxPIkappaBalphadeltaN, dNflox, IkBaDeltaN(loxP-DeltaN) |
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Gene:
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Ctnnb1
Location:
Chr9:120929216-120960507 bp, + strand
Genetic Position: Chr9,
72.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71744
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele is similar to Catnnb1tm1(Nfkbia)Rsu in that an Nfkbia cDNA encoding amino acids 71 through 317 was inserted at the start codon of Catnnb1, but in this case, a floxed stop cassette preceded the Nfkbia sequence, precluding its expression. As in Catnnb1tm1(Nfkbia)Rsu, the coding region of the first coding exon and the following 4 downstream exons were deleted. (J:71744)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ctnnb1 Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:71744
Schmidt-Ullrich R et al.,
"Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices."
Development 2001 Oct;128(19):3843-53
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All: |
7 reference(s)
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Analysis Tools
