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| Nomenclature |
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Symbol:
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Tg(Mt1-RET)304Ina
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Name:
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transgene insertion 304, Izumi Nakashima
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MGI ID: |
MGI:3039777 |
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Synonyms: |
MT-ret |
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Transgene:
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Tg(Mt1-RET)304Ina
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(BALB/c x C57BL/6) X BALB/c
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Human RET proto-oncogene cDNA driven by the mouse metallothionein 1 promoter/enhancer. This mouse is predicted to have 5 copies of the transgene. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Founder only. Lines 304a, 304b, and 304c were derived from this mouse. Additional founder numbers: 108, 192, 207, 242, 301, 319.
Phenotypic Similarity to Human Syndrome: Giant Congenital Melanocytic Nevus (J:50392)
Phenotypic Similarity to Human Syndrome: multistep melanoma (Tg(Mt1-RET)304Ina/0 in J:155735)
Phenotypic Similarity to Human Syndrome: de novo melanoma (for Ednrbtm1Ywa/Ednrb+ Tg(Mt1-RET)304Ina/0 in J:155735)
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| References |
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Original: |
J:70622
Iwamoto T et al.,
"Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene."
EMBO J 1991 Nov;10(11):3167-75
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All: |
28 reference(s)
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Analysis Tools
