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| Nomenclature |
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Symbol:
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Tg(Th-MYCN)41Waw
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Name:
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transgene insertion 41, William A Weiss
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MGI ID: |
MGI:3039395 |
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Synonyms: |
MYCN, Th-MYCN, TH-NMYC |
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Transgene:
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Tg(Th-MYCN)41Waw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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BALB/c and C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The rat tyrosine hydrolase promoter directs expression of human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen. (J:41126)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice carrying this transgene on a 129X1/SvJ background are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors from these mice have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.
Phenotypic Similarity to Human Syndrome: neuroblastoma
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| References |
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Original: |
J:41126
Weiss WA et al.,
"Targeted expression of MYCN causes neuroblastoma in transgenic mice."
EMBO J 1997 Jun 2;16(11):2985-95
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All: |
22 reference(s)
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Analysis Tools
