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| Nomenclature |
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Symbol:
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Cdkn1atm2(HBx)Xya
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Name:
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cyclin-dependent kinase inhibitor 1A (P21);
targeted mutation 2, Xiao Yang
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MGI ID: |
MGI:3039363 |
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Synonyms: |
p21HBx |
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Gene:
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Cdkn1a
Location:
Chr17:29090979-29100722 bp, + strand
Genetic Position: Chr17,
15.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88078
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Exon 2 was replaced with a floxed neo cassette and sequence encoding the hepatitis B virus surface antigen (HBx). Endogenous transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:88078)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cdkn1a Mutation:
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41 strains or lines available |
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| References |
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Original: |
J:88078
Wang Y et al.,
"HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice."
Hepatology 2004 Feb;39(2):318-24
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All: |
3 reference(s)
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Analysis Tools
