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| Nomenclature |
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Symbol:
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Trp53tm3.1Tyj
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Name:
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transformation related protein 53;
targeted mutation 3.1, Tyler Jacks
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MGI ID: |
MGI:3039266 |
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Synonyms: |
p53H, p53R270H, p53 R270H, Trp53R270H |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95316
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: The loxP flanked stop cassette was removed from Trp53tm3Tyj via cre-mediated recombination, leaving an R270H missense mutation in exon 8. Quantitative real-time PCR confirmed that the point mutation allele was expressed at a level comparable to wild-type. (J:95316)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:95316
Olive KP et al.,
"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome."
Cell 2004 Dec 17;119(6):847-60
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All: |
9 reference(s)
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Analysis Tools
